Accession Number : ADA316819

Title :   Proposal for Research in Quantitative Bioassay Methodology and Risk Analysis and Characterization.

Descriptive Note : Final rept. 11 Jan 93-30 Sep 95,

Corporate Author : NAVAL POSTGRADUATE SCHOOL MONTEREY CA

Personal Author(s) : Gaver, Donald P.

PDF Url : ADA316819

Report Date : SEP 1995

Pagination or Media Count : 119

Abstract : The use of canonical correlation to combine information from biological testing systems is discussed. A graphical procedure to combine results from biological test systems is proposed. Results are presented of analyses of data from health screens to monitor the health status of medaka used in toxicological studies. A statistical model that incorporates a non-ignorable missing data mechanism is proposed to study the effect of leukocrit values which are not measurable. Results are presented of analyses of pathology data from the six month interim sacrifice of the West Branch Canal Creek Carcinogenicity Study with Medaka, Test 4O1-OO2R.

Descriptors :   *CORRELATION, *CARCINOGENS, *TOXICOLOGY, TEST AND EVALUATION, MATHEMATICAL MODELS, METHODOLOGY, RISK, BIOLOGY, GRAPHICS, STATISTICAL ANALYSIS, PATHOLOGY, STREAMS, CANALS, BIOASSAY.

Subject Categories : Biochemistry
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE