Accession Number : ADA317190

Title :   Range-Finding Study for a Reproductive Screen of Modular Artillery Charge System (XM231/XM232) Administered in the Diet of Sprague-Dawley Rats.

Descriptive Note : Final rept. Feb-Mar 95,

Corporate Author : MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH

Personal Author(s) : Kinkead, E. R. ; Freedman, M. L. ; Wolfe, R. E. ; Fleming, C. D. ; Pollard, D. L.

PDF Url : ADA317190

Report Date : APR 1995

Pagination or Media Count : 29

Abstract : An artillery propellant under development b the U.S. Army is a granular mixture of nitrocelinlose, nitroglycerin, nitroguanidine, ethylcentralite, cryolite, and graphite. The propellant, Modniar Artillery Charge System or MACS, consists of a single increment of propellant charge contained within a rigid combustible casing. Nitrocellulose, nitroglycerin, and nitroguanidine make up greater than 98% of the total propellant mixture. As part of the process to develop environmental and health effects criteria, a 90-day modified Screening Information Data Set reproductive assay is planned. In order to provide information on clinical signs, methemoglobin formation and possible target organs, as well as determine dose levels, a range- finding study was performed. Male and female Sprague-Dawley rats were treated with diet containing either O.O,0.2S, or 2.Og propellant/kg diet for a three-week period. No mortalities occurred and body weights were unaffected by treatment. Methemoglobin concentrations measured at the conclusion of the study indicated no differences between treated and control rats. Relative liver weights of the high-dose female rats were significantly (p<0. 1) greater than the control group. No gross lesions were noted at necropsy.

Descriptors :   *TOXICITY, *ARTILLERY, *NITROCELLULOSE, *REPRODUCTION(PHYSIOLOGY), *NITROGLYCERIN, CONTROL, ENVIRONMENTS, RATS, HEALTH, CLINICAL MEDICINE, SIGNS AND SYMPTOMS, MODULAR CONSTRUCTION, GRAPHITE, TARGETS, MIXTURES, ENVIRONMENTAL IMPACT, PROPELLANTS, WEIGHT, DOSAGE, LEVEL(QUANTITY), STANDARDS, LIVER, RANGE FINDING, DIET, RIGIDITY, PROPELLING CHARGES, BODY WEIGHT, FEMALES, METHEMOGLOBIN, AUTOPSY, LESIONS, ORGANS(ANATOMY), NITROGUANIDINE, COMBUSTIBLE CARTRIDGE CASES.

Subject Categories : Anatomy and Physiology
      Toxicology
      Organic Chemistry
      Plastics

Distribution Statement : APPROVED FOR PUBLIC RELEASE