Accession Number : ADA318218

Title :   WRAIR GOCO Blood Research Detachment's Red Blood Cell Storage Laboratory.

Descriptive Note : Annual rept. 21 Sep 95-20 Sep 96,

Corporate Author : BIONETICS CORP HAMPTON VA

Personal Author(s) : Lippert, Lloyd E.

PDF Url : ADA318218

Report Date : OCT 1996

Pagination or Media Count : 71

Abstract : A research laboratory to support red blood cell preservation research was staffed and maintained at the Blood Research Detachment, 1413 Research Boulevard, Rockville, MD 20850. Two clinical trials evaluating candidate red cell preservation systems for eight week red cell storage were initiated. The data collection was completed on the first study; the second is ongoing. A facility to manufacture acellular hemoglobin solutions and a quality control laboratory to support the in-process and product release testing requirements of the production facility were staffed and maintained until 20 September. Six additional hemoglobin production process improvement were instituted which, when combined with previous fiscal year process improvements, increased the purity by 30%, increased yield by 25% and reduced production time. Prior to the production facility closure, 106.041 of hemoglobin solution containing 11.32 kg hemoglobin was manufactured which met or exceeded contract specifications, two specialty hemoglobin products were produced, lipisome encapsulated hemoglobin was prepared, and facility was prepared for indefinite shut-down. The Blood Research Detachment's mission was supported.

Descriptors :   *HEMOGLOBIN, *BLOOD SUBSTITUTES, *BLOOD CELLS, *BLOOD STORAGE, TEST AND EVALUATION, REQUIREMENTS, CLOSURES, CONTRACTS, PRODUCTION, SPECIFICATIONS, FACILITIES, RESEARCH FACILITIES, REDUCTION, TIME, MISSIONS, PRODUCTION CONTROL, QUALITY CONTROL, RELEASE, DATA ACQUISITION, ENCAPSULATION, LABORATORIES, STORAGE, ERYTHROCYTES, BLOOD.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE