Accession Number : ADA319343

Title :   Regulation of Anchorage-Independent Growth in Breast Cancer: Role of Signalling by Extracellular Matrix and Growth Factors.

Descriptive Note : Annual rept. 1 Aug 95-29 Jul 96,

Corporate Author : QUEEN'S UNIV KINGSTON (ONTARIO)

Personal Author(s) : Saulnier, Ron

PDF Url : ADA319343

Report Date : AUG 1996

Pagination or Media Count : 31

Abstract : Our main goal is to better understand the mechanisms by which extracellular matrix and growth factors can promote anchorage-independent growth of a murine mammary carcinoma cell line. Our objectives are to investigate: (l) (a) the role of fibronectin and the alpha 5 Beta 1 integrin in SP1 cell survival as well as, (b) the phosphorylation status of FAK under anchorage independent conditions; (2) the role of HGF and TGF-Beta in SP1 mediated cell survival; (3) and the role of PI 3-kinase in SP1 cell survival and anchorage-independent growth.

Descriptors :   *GROWTH(PHYSIOLOGY), *BREAST CANCER, SURVIVABILITY, CANADA, SIGNALS, CELLS(BIOLOGY), PHOSPHORYLATION, PHOSPHORUS TRANSFERASES.

Subject Categories : Biochemistry
      Medicine and Medical Research
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE