Accession Number : ADA319641

Title :   Extrathalamic Modulation of Cortical Responsiveness.

Descriptive Note : Final technical rept. 1 Jul 93-30 Jun 96,

Corporate Author : CALIFORNIA UNIV SAN DIEGO LA JOLLA DEPT OF PSYCHIATRY

Personal Author(s) : Foote, Stephen L.

PDF Url : ADA319641

Report Date : 17 NOV 1996

Pagination or Media Count : 10

Abstract : The overall goal of the proposed studies was to further elucidate the mechanisms by which the brainstem noradrenergic (NA) nucleus, locus coeruleus (LC), is capable of altering forebrain electrophysiological activity. The proposed studies had the following Specific Aims: (1) To examine the relationship between the intensity of LC neuronal activity, forebrain EEG activation, and rates of NA release in neocortex and hippocampus using microdialysis; (2) To test the hypothesis that LC-induced activation of forebrain EEG is mediated by LC/NA actions on septal and basal forebrain neurons; (3) To examine, in unanesthetized monkey, the effects of activating or inactivating the LC/NA system on forebrain EEG and on dialysis measures of NA and acetylcholine release in neocortex and hippocampus. The effects on these dialysis measures of systemic adrenergic drugs that alter cognitive performance was to be determined; (4) To examine, in monkey, the effects of activating or inactivating the LC/NA system on cortical and hippocampal EEG measures and on complex, bimanual motor behavior.

Descriptors :   *RESPONSE(BIOLOGY), *MODULATION, *CEREBRAL CORTEX, *THALAMUS, ACTIVATION, BRAIN, COGNITION, NERVE CELLS, DRUGS, HIPPOCAMPUS, ELECTROENCEPHALOGRAPHY, SYMPATHETIC NERVOUS SYSTEM, MONKEYS, MOTOR NEURONS, ELECTROPHYSIOLOGY, CEREBRUM, ACETYLCHOLINE, SYMPATHOLYTIC AGENTS.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE