Accession Number : ADA319732

Title :   Poliovirus Tumor Vaccine for Breast Cancer Micro-Metastases.

Descriptive Note : Annual rept. 15 Aug 95-14 Aug 96,

Corporate Author : ALABAMA UNIV IN BIRMINGHAM

Personal Author(s) : Morrow, Casey D.

PDF Url : ADA319732

Report Date : SEP 1996

Pagination or Media Count : 9

Abstract : The underlying reason for failure to cure patients diagnosed with breast cancer is the presence of micrometastases. The stimulation of anti-tumor immune responses represents one of the most effective ways to treat low tumor burdens that are microscopically or clinically occult. The objective of our proposal is to determine whether a poliovirus replicon vaccine strategy engineered to express human CEA or the HER2/neu oncogene can induce systemic immunity and eradication of micrometastases.

Descriptors :   *NEOPLASMS, *VACCINES, *METASTASIS, *POLIOVIRUSES, *BREAST CANCER, STIMULATION(PHYSIOLOGY), HUMANS, CLINICAL MEDICINE, ANTIBODIES, GENES, RESPONSE(BIOLOGY), MICE, IMMUNITY, OCCULTATION.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research
      Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE