Accession Number : ADA319732
Title : Poliovirus Tumor Vaccine for Breast Cancer Micro-Metastases.
Descriptive Note : Annual rept. 15 Aug 95-14 Aug 96,
Corporate Author : ALABAMA UNIV IN BIRMINGHAM
Personal Author(s) : Morrow, Casey D.
PDF Url : ADA319732
Report Date : SEP 1996
Pagination or Media Count : 9
Abstract : The underlying reason for failure to cure patients diagnosed with breast cancer is the presence of micrometastases. The stimulation of anti-tumor immune responses represents one of the most effective ways to treat low tumor burdens that are microscopically or clinically occult. The objective of our proposal is to determine whether a poliovirus replicon vaccine strategy engineered to express human CEA or the HER2/neu oncogene can induce systemic immunity and eradication of micrometastases.
Descriptors : *NEOPLASMS, *VACCINES, *METASTASIS, *POLIOVIRUSES, *BREAST CANCER, STIMULATION(PHYSIOLOGY), HUMANS, CLINICAL MEDICINE, ANTIBODIES, GENES, RESPONSE(BIOLOGY), MICE, IMMUNITY, OCCULTATION.
Subject Categories : Biochemistry
Genetic Engineering and Molecular Biology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE