Accession Number : ADA319733
Title : Identification and Genetic Mapping of Genes for Hereditary Breast and Ovarian Cancer in Families Unlinked to BRCA1.
Descriptive Note : Annual rept. 22 Aug 95-21 Aug 96,
Corporate Author : UTAH UNIV SALT LAKE CITY
Personal Author(s) : Neuhausen, Susan L.
PDF Url : ADA319733
Report Date : SEP 1996
Pagination or Media Count : 11
Abstract : Since the last annual report, the BRCA2 gene was cloned by our collaborator on this grant. We identified the complete BRCA2 sequence which encodes a protein of 3,418 amino acids. Due to the successful completion of several of the aims, we added additional goals. We have identified predisposing mutations in six of our families and a polymorphism in a seventh. We are continuing to screen for mutations in our additional families using SSCP. Now that the gene has been isolated and mutations are being identified rapidly, we are constructing a database of haplotypes of mutations. In a collaborative project, we will examine common mutations to investigate mutation origin.
Descriptors : *GENES, *GENETICS, *CANCER, *GENETIC MAPPING, *OVARIES, *BREAST CANCER, DATA BASES, PROTEINS, ISOLATION, MUTATIONS, CODING, CLONES, AMINO ACIDS, POLYMORPHISM.
Subject Categories : Biochemistry
Genetic Engineering and Molecular Biology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE