Accession Number : ADA319774

Title :   Isolation of a Receptor for WNT/Wingless Growth Factors.

Descriptive Note : Annual rept. 1 Sep 95-31 Aug 96,

Corporate Author : STANFORD UNIV CA

Personal Author(s) : Nusse, Roel

PDF Url : ADA319774

Report Date : SEP 1996

Pagination or Media Count : 32

Abstract : The work done in this grant aims at elucidating the function of the Wnt signaling molecules in cancer. Wnt proteins are secreted and play important roles in the control over growth, in particular in the mammary gland. Wnt genes can also can act as oncogenes in mouse mammary tumors. The work is specifically aimed at identifying a receptor for Wnt proteins. The isolation of a receptor is critical to our understanding of the mechanism of action of Wnt proteins. Using genetic and biochemical approaches we wish to identify and to clone the receptor for a Wnt gene product in Drosophila, called wingless. The receptor will be characterized and using the receptor gene, we will subsequently clone mammalian Wnt receptors by homology. During the past year, we have accomplished this goal, as a receptor for wingless has been identified.

Descriptors :   *MAMMARY GLANDS, *DROSOPHILA, *BREAST CANCER, MOLECULES, BIOCHEMISTRY, PROTEINS, NEOPLASMS, GENES, CLONES, MICE, GENETICS, SENSE ORGANS, GROWTH(PHYSIOLOGY).

Subject Categories : Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE