Accession Number : ADA319776

Title :   The Role of Alveolar Macrophages and Chemical Mediators in a Model of Smoke-Induced Lung Injury.

Descriptive Note : Final rept. 22 Nov 93-21 Nov 96,

Corporate Author : ARIZONA UNIV TUCSON

Personal Author(s) : Witten, Mark L.

PDF Url : ADA319776

Report Date : DEC 1996

Pagination or Media Count : 27

Abstract : Using a rabbit model of lung injury to simulate fire-related transport accidents and military combat situations, our studies have demonstrated that toxic products of combustion cause a severe inflammatory reaction in the lung parenchyma as evidenced by gas exchange, WtL/WtB, O2- and TNF -alpha by PAM in vitro, and pathological evidence. It was suggested that pulmonary alveolar macrophages play an important role in the early phase of acute lung injury through production of oxygen radicals and cytokines. Standard doses of U75412E (1% in saline) were aerosolized and ventilated into the rabbit lungs via an endotracheal tube either before or after smoke exposure, suggesting the treatment with U75412E significantly prevented or limited the extent of acute lung injury due to smoke insult. It is postulated that lazaroids may possibly be associated with the oxygen radicals-initiated processes which activate cytokine gene transcription and initiate the cytokine cascade as a result of the smoke insult. Also our findings have demonstrated that this lazaroid may be more effective as a rescue agent rather than a prophylactic agent for acute smoke-induced lung injury. The additional benefit from dose- and time-effects of U75412E remain to be experimentally demonstrated.

Descriptors :   *TOXICITY, *SMOKE, *LUNG, *WOUNDS AND INJURIES, *ALVEOLI, MILITARY PERSONNEL, RESCUES, IN VITRO ANALYSIS, OXYGEN, PATHOLOGY, EXPOSURE(PHYSIOLOGY), INFLAMMATION, MACROPHAGES, INDUCED ENVIRONMENTS, PREVENTIVE MEDICINE, RABBITS, GAS EXCHANGE(BIOLOGY), CHEMICAL RADICALS, PULMONARY ARTERIES.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE