Accession Number : ADA319987

Title :   PET-FDG Imaging in Metastatic Breast Cancer Treated with High Dose Chemotherapy and Stem Cell Support.

Descriptive Note : Annual rept. 1 Sep 95-31 Aug 96,

Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA

Personal Author(s) : Alavi, Abass

PDF Url : ADA319987

Report Date : SEP 1996

Pagination or Media Count : 14

Abstract : This study is designed to assess the effectiveness of positron emission tomography (PET) with fluorodeoxyglucose in patients with metastatic breast cancer undergoing high dose chemotherapy with stem cell rescue. It includes patients enrolled on two high dose chemotherapy trials (PBT-1 and UPCC #3195). So far, 24 patients have been enrolled in the protocol, and the study is proceeding as planned. We have performed a preliminary analysis of the PET studies of 17 patients performed before high dose chemotherapy. In this subgroup of patients, 11 had active disease demonstrated on the PET study, and 6 had no evidence of metabolically active disease. Three subjects had disease involvement demonstrated only on PET imaging, and in one case, PET confirmed the clinical impression of responding liver metastases shown on CT. Several repeat studies have been performed and will be analyzed when enough prognostic information becomes available. Patient accrual is ongoing and the study is proceeding as scheduled. PET FDG imaging is a promising tool that can potentially predict early therapeutic failure.

Descriptors :   *IMAGE PROCESSING, *EMISSION, *TOMOGRAPHY, *POSITRONS, *METASTASIS, DISEASES, DOSAGE, LIVER, CHEMOTHERAPY, BREAST CANCER.

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE