Accession Number : ADA320200

Title :   Normal and Ischemic Myocardial Transport Kinetics for Bis(N-ethoxy, N-ethyl Dithiocarbamato) Ditrido Technetium-99m (NOET).

Descriptive Note : Master's thesis,

Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH

Personal Author(s) : Harms, Terrance A.

PDF Url : ADA320200

Report Date : 09 JAN 1997

Pagination or Media Count : 78

Abstract : Recently a new Tc-99m labeled compound bis(N-ethoxy, N-ethyl dithiocarbamato) nitrido Tc-99m, or NOET, has been designed to evaluate regional myocardial blood flow and cellular viability. Previous studies of NOET indicate that it has the potential for use as a perfusion agent for assessing myocardial viability. These studies however were not designed to evaluate the actual kinetics of this agent. In the present study, Thermoluminscent Dosimeter (TLD) analysis was used in a rabbit model to assess the transport kinetics of NOET in normal and ischemic myocardium. The final rate constants for clearance in the normal and ischemic regions were 7.58E-4 + or - 1.1E-4 (1sigma) minutes-1 and 9.59E-4 + or - 3.6E-4 (1sigma) minutes-1, respectively. These compare to the arterial clearance rate constant of 4.81E-3 + or - 1.2E-3 (1sigma) minutes-1. Therefore, findings indicate that NOET has the potential to assess myocardial viability.

Descriptors :   *RADIOACTIVE ISOTOPES, *BLOOD CIRCULATION, *MYOCARDIUM, *ISCHEMIA, *CORONARY ARTERIES, CONSTANTS, VIABILITY, TRANSPORT, KINETICS, DOSIMETERS, RABBITS, ANATOMICAL MODELS, PERFUSION, CYTOLOGY.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE