Accession Number : ADA320226

Title :   Morphological Manifestations of Parvovirus B19 Infection in the Bone Marrow.

Descriptive Note : Master's thesis,

Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH

Personal Author(s) : More, Lucia E.

PDF Url : ADA320226

Report Date : 09 JAN 1997

Pagination or Media Count : 62

Abstract : Parvovirus B19 (PV B19) preferentially infects erythroid progenitor cells in the bone marrow, frequently causing anemia along with transient aplastic crisis and pure red cell aplasia. The giant normoblast, previously described as the classic marrow finding, is not a highly sensitive indicator of infection. We devised a highly sensitive two-round, nested PCR procedure to detect PV B19. Eight of 78 clinical specimens from individuals with unexplained cytopenias which tested positive by this method, were studied to define the effects of this virus. Examination of the bone marrow of these patients revealed a spectrum of morphological manifestations including: the giant normoblast, hypocellular marrow, hypercellular marrow, interstitial depletion, red cell aplasia, erythroid hyperplasia and evidence of erythroid dysplasia. The heterogeneity of these findings may reflect atypical immune responses leading to a prolonged course in some patients.

Descriptors :   *DEOXYRIBONUCLEIC ACIDS, *INFECTIOUS DISEASES, *BONE MARROW, *DYSPLASIA, DEPLETION, PRECURSORS, SENSITIVITY, INTERSTITIAL, PURITY, RESPONSE(BIOLOGY), BLOOD SERUM, IMMUNITY, ERYTHROCYTES, CELLS(BIOLOGY), INDICATORS, HEPATITIS, DYSFUNCTION, ANEMIAS, BLOOD DONORS.

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE