Accession Number : ADA320255

Title :   Preclinical Pharmacodynamic and Pharmacokinetic Studies of Investigational New Drugs.

Descriptive Note : Annual rept. 2 Nov 95-1 Nov 96,

Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL

Personal Author(s) : Noker, Patricia

PDF Url : ADA320255

Report Date : NOV 1996

Pagination or Media Count : 18

Abstract : During the past year of the contract, a study was initiated to evaluate, in dogs, whether significant clinical or pharmacological interactions occur when single oral doses of the antimalarial drug WR238605 are given in combination with one of the following schizonticidal agents: mefloquine, halofantrine, chloroquine or quinine/doxycycline. An initial pilot experiment was conducted to obtain a profile of the plasma kinetics of each schizonticidal agent alone and in combination with WR238605 in order to establish optimal times for sample collection and physiological evaluations in a subsequent main experiment. No gross adverse physiological effects were observed when WR238605 was undiminished alone or in combination with the individual schizonticidal agents. Analyses of the plasma samples for drug concentrations have not been completed to date. Thus, conclusions relevant to possible kinetic interactions between WR238605 and the other schizonticidal agents cannot be drawn at this time.

Descriptors :   *PHYSIOLOGICAL EFFECTS, *PHARMACOKINETICS, *DRUGS, *PHARMACOLOGY, *ORAL DOSAGE, *CHLOROQUINE, *QUININE, TEST AND EVALUATION, OPTIMIZATION, INTERACTIONS, PLASMAS(PHYSICS), CLINICAL MEDICINE, ADVERSE CONDITIONS, PILOT STUDIES, CONCENTRATION(CHEMISTRY), DOGS.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE