Accession Number : ADA320262

Title :   Biochemistry and Chemotherapy of Malaria and Leishmaniasis.

Descriptive Note : Annual rept. 2 Nov 95-1 Nov 96,

Corporate Author : MASSACHUSETTS UNIV AMHERST

Personal Author(s) : Nolan, Linda L.

PDF Url : ADA320262

Report Date : DEC 1996

Pagination or Media Count : 31

Abstract : Leishmaniasis, a disease caused by protozoan parasites of the Leishmania ssp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease are either ineffective or toxic. Malaria is considered to be the most important infectious disease of humans on a world-wide scale. It is estimated that 300 million persons are infected at any one time in the world. The purpose of this work is to aid in the development of an effective, nontoxic treatment for leishmaniasis and malaria. The objective of this research was to: (1) complete testing of potential WRAIR compounds on L. mexicana DNA synthetic enzymes, (2) establish in vitro cultivation of Plasmodium falciparum; and (3) develop an antimalarial drug-evaluation system that incorporates both in vitro P. falciparum viability and DNA synthetic enzyme inhibitor protocols.

Descriptors :   *PARASITES, *MALARIA, *INFECTIOUS DISEASES, *LEISHMANIASIS, *CHEMOTHERAPY, GLOBAL, HUMANS, BIOCHEMISTRY, DEOXYRIBONUCLEIC ACIDS, IN VITRO ANALYSIS, SCALE, VIABILITY, THERAPY, PUBLIC HEALTH, PLASMODIUM FALCIPARUM, ANTIMALARIALS, PROTOZOA, ENZYME INHIBITORS.

Subject Categories : Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE