Accession Number : ADA320327

Title :   Biological Applications of STM & AFM in Water/High Resolution Microscopy of Nucleoprotein Complexes in Water.

Descriptive Note : Final rept. 1 Jan 90-30 Sep 96,

Corporate Author : ARIZONA STATE UNIV TEMPE

Personal Author(s) : Lindsay, S. M.

PDF Url : ADA320327

Report Date : 30 SEP 1996

Pagination or Media Count : 5

Abstract : Sample preparation methods and new instrumentation have been developed for the study of biological molecules in their native (aqueous) environment by scanning tunneling microscopy (STM) and atomic force microscopy (AFM). Information from STM is complicated by the many different electron transfer mechanisms, so structural information is difficult to obtain. However, chemical identification of certain electroactive molecules may be possible at the single molecule level. A new AFM with a magnetically-oscillated tip was used to generate images of DNA of unprecedented resolution. The DNA was imaged in-situ, spontaneously adsorbed to mica in the presence of divalent ions.

Descriptors :   *SCANNING ELECTRON MICROSCOPES, *WATER, *TUNNELING(ELECTRONICS), *ELECTRON MICROSCOPY, *NUCLEOPROTEINS, IONS, BIOLOGY, MOLECULES, STRUCTURAL PROPERTIES, ADSORPTION, ELECTRONIC SCANNERS, HIGH RESOLUTION, DEOXYRIBONUCLEIC ACIDS, IMAGES, INSTRUMENTATION, ELECTRON TRANSFER, CHEMICAL ANALYSIS.

Subject Categories : Test Facilities, Equipment and Methods
      Quantum Theory and Relativity

Distribution Statement : APPROVED FOR PUBLIC RELEASE