Accession Number : ADA321029
Title : Mechanism of Abnormal Cell-Extracellular Matrix Interactions in Human Breast Cancer.
Descriptive Note : Annual rept. 1 Oct 95-30 Sep 96,
Corporate Author : CALIFORNIA UNIV BERKELEY LAWRENCE BERKELEY LAB
Personal Author(s) : Chen, Huei-Mei
PDF Url : ADA321029
Report Date : OCT 1996
Pagination or Media Count : 20
Abstract : In our previous annual report, we summarized the accomplishment made towards each of the three specific aims stated in the original grant proposal and we listed the corresponding manuscript and publication generated from those data. Here, we would like to reiterate the objectives of the grant proposal: to characterize the molecular mechanisms by which normal versus tumor breast cells interact with their ECM and the microenvironment, and to determine the functional significance of this interaction and to examine the role of ECM/cell signaling in turmorigenesis. Functions of classical tumor suppressor genes, both Rb and genes on chromosome 11, on the behavior of mammary epithelial cells in 3-D cultures is discussed. Future studies will focus on implementing molecular biology approaches to provide fundamental clues to the mechanisms underlying the breast tumor development.
Descriptors : *CELLS(BIOLOGY), *ABNORMALITIES, *BREAST CANCER, EPITHELIUM, MEMBRANES(BIOLOGY), HUMANS, NEOPLASMS, CHROMOSOMES, SIGNALS, ANTIBODIES, MOLECULAR BIOLOGY, GENES, MOLECULAR PROPERTIES, CULTURES(BIOLOGY), RECEPTOR SITES(PHYSIOLOGY), MAMMARY GLANDS, SUPPRESSORS, METASTASIS.
Subject Categories : Biochemistry
Genetic Engineering and Molecular Biology
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE