Accession Number : ADA321147

Title :   Hormone Resistance and Progesterone Receptors in Breast Cancer.

Descriptive Note : Annual rept. 15 Jun 95-14 Jun 96,

Corporate Author : COLORADO UNIV HEALTH SCIENCES CENTER DENVER

Personal Author(s) : Horwitz, Kathryn B.

PDF Url : ADA321147

Report Date : AUG 1996

Pagination or Media Count : 107

Abstract : We postulate that breast cancers become "resistant" to hormone therapy because antagonists acquire inappropriate, agonist-like, effects. The clinical consequences of such a functional switch are grave. The studies we have proposed address the molecular mechanism by which antagonist-occupied progesterone B-receptors become transcriptional agonists. Purpose of Present Work: Aim 1. The functional differences between A and B-receptors in breast cancer cells. Aim 2. BUS - The B-upstream segment. A third transcriptional activation domain unique to B-receptors? Aim 3. Mechanisms of AF-3 action in the BUS segment.

Descriptors :   *HORMONES, *RESISTANCE, *PROGESTERONE, *BREAST CANCER, MOLECULES, DEOXYRIBONUCLEIC ACIDS, MOLECULAR BIOLOGY, CELLS(BIOLOGY), RIBONUCLEIC ACIDS, RECEPTOR SITES(PHYSIOLOGY), ENDOCRINOLOGY.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE