Accession Number : ADA321164

Title :   The Role of p53 in Human Breast Cancer.

Descriptive Note : Annual rept. 1 Sep 95-31 Aug 96,

Corporate Author : TEXAS UNIV SOUTHWESTERN MEDICAL SCHOOL AT DALLAS

Personal Author(s) : Shay, Jerry W.

PDF Url : ADA321164

Report Date : SEP 1996

Pagination or Media Count : 111

Abstract : The principal objectives are to: (1) Transfect p53 mutants commonly observed in human breast cancer into normal human mammary epithelial cells obtained from different donors and isolate clones; (2) Characterize the clones for extension of lifespan and immortalization; (3) Determine in breast epithelial cells immortalized and expressing mutant pS3 if expression of the mutant p53 is necessary for the maintenance of growth; (4) Determine if expression of any of the p53 mutants provide a selective growth advantage to breast epithelial cells prior to immortalization; (5) Determine downstream genomic targets of p53 that may be important in the development and progression of breast cancer.

Descriptors :   *HUMANS, *GENES, *BREAST CANCER, MAINTENANCE, EPITHELIUM, MUTATIONS, CHROMOSOMES, CLONES, LIFE SPAN(BIOLOGY), CELLS(BIOLOGY), EVOLUTION(DEVELOPMENT), MAMMARY GLANDS, GROWTH(PHYSIOLOGY).

Subject Categories : Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE