Accession Number : ADA321549

Title :   Neural Responses to Injury: Prevention, Protection, and Repair. Volume 7: Role of Growth Factors and Cell Signaling in the Response of Brain and Retina to Injury.

Descriptive Note : Annual technical rept. 20 Sep 94-19 Sep 95,

Corporate Author : LOUISIANA STATE UNIV MEDICAL CENTER NEW ORLEANS

Personal Author(s) : Bazan, Nicolas G. ; Deininger, Prescott

PDF Url : ADA321549

Report Date : 1995

Pagination or Media Count : 41

Abstract : Head injury triggers a time sequence of biochemical changes that can result in either cell death or wound healing and recovery. Second messengers are released as a consequence of cell signal transduction activation by trauma. Some of these messengers may target the nucleus and activate gene expression (Bazan, 1994). As a result, new signal molecules such as cytokines and peptide growth factors can be generated, released from the cells, and can interact with receptors in other cells. The cellular responses generated can have positive (repair) or negative (death) consequences. This project aims to contribute to a better understanding of the role of specific growth factors, the differentiation of growth factors, neurotrophic factors and cytokines in development, and wound healing in the central nervous system (CNS) and eye. We had two goals in our original proposal. The first was to use our dominant negative mutants for PDGF to specifically lower neuronal PDGF expression, in order to determine if either development or the response to wound models was altered. These experiments are well under way. Our second goal was to survey gene expression, using several injury models, for a number of genes thought to participate in the repair process after brain injury.

Descriptors :   *BRAIN, *WOUNDS AND INJURIES, *RETINA, *HEAD(ANATOMY), ACTIVATION, MOLECULES, PEPTIDES, BIOCHEMISTRY, MUTATIONS, SEQUENCES, REPAIR, NERVOUS SYSTEM, GENES, TRANSDUCERS, EYE, DEATH, CELLS(BIOLOGY), CENTRAL NERVOUS SYSTEM, TRAUMA, HEALING, TRIGGER CIRCUITS, GROWTH(PHYSIOLOGY).

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE