Accession Number : ADA321550

Title :   Neural Responses to Injury: Prevention, Protection, and Repair. Volume 8: Protecting the Auditory System and Prevention of Hearing Problems.

Descriptive Note : Annual technical rept. 20 Sep 94-19 Sep 95,

Corporate Author : LOUISIANA STATE UNIV MEDICAL CENTER NEW ORLEANS

Personal Author(s) : Bazan, Nicolas G. ; Bobbin, Richard ; Berlin, Charles

PDF Url : ADA321550

Report Date : 1995

Pagination or Media Count : 136

Abstract : ANIMAL PROJECT: The SPECIFIC AIMS of this study are to demonstrate and explore mechanisms for preventing the effects of intense sound. In years 01 and 02 we discovered that continuous, ipsilateral primary stimulation (CM-LIPS) will produce complex changes in the cochlea and that L-type Ca2+ channels are involved. We discovered that exposure to a very low level continuous noise (64 dB SPL for 10-11 days) results in changes in cochlear partition mechanics and in the response of OHCs (and possibly the supporting cells) to ATP. HUMAN PROJECT: Major findings since last year include: (1) binaural stimulation with tone bursts generates more than three times the emission suppression of ipsilateral or contralateral stimulation in a forward masking paradigm when the stimuli are below 70 dB SPL; (2) Females show larger emissions than males; (3) Using tone bursts we can show more controllable and measurable emission than using broad band clicks. Twenty musician subjects are in different stages of study at present, and 20 more are being sought.

Descriptors :   *STIMULATION(PHYSIOLOGY), *NERVOUS SYSTEM, *WOUNDS AND INJURIES, *HEARING, *COCHLEA, EMISSION, FORWARD AREAS, HUMANS, INTENSITY, MECHANICS, REPAIR, RESPONSE, SOUND, ANIMALS, MALES, CELLS(BIOLOGY), MASKING, SUPPRESSION, FEMALES, PREVENTIVE MEDICINE.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE