Accession Number : ADA321551

Title :   Neural Responses to Injury: Prevention, Protection, and Repair. Volume 2: Repair and Regeneration of Peripheral Nerve Damage. Revised.

Descriptive Note : Annual technical rept. 20 Sep 94-19 Sep 95,

Corporate Author : LOUISIANA STATE UNIV MEDICAL CENTER NEW ORLEANS

Personal Author(s) : Bazan, Nicolas G. ; Beuerman, Roger ; Kline, David ; Sumner, Austin

PDF Url : ADA321551

Report Date : JAN 1996

Pagination or Media Count : 122

Abstract : The overall focus of this project has been to understand the cellular and molecular biology of neuroma formation as a complication of damage and repair to peripheral nerves. As part of this, a secondary focus has been to establish in vitro models of cell lines of fibroblasts from peripheral nerves that can be used to uncover the molecular mechanisms of peripheral nerve fibroblast response to damage and also to their interaction with cell signaling molecules that may be present in the repair process. A third objective has been to understand the origin of pain that accompanies neuroma formation. It has not been known how the cellular developments affect the physiology of the entrapped nerve endings. Electrophysiological and immunohistochemical studies have been carried out on human neuroma tissue to determine how the ion channels change as the neuroma develops.

Descriptors :   *IN VITRO ANALYSIS, *NERVOUS SYSTEM, *WOUNDS AND INJURIES, *FIBROBLASTS, *NERVES, TISSUES(BIOLOGY), DAMAGE, NEOPLASMS, REPAIR, RESPONSE, SIGNALS, MOLECULAR BIOLOGY, PHYSIOLOGY, HUMAN BODY, PAIN, CELLS(BIOLOGY), MOLECULAR PROPERTIES, CHANNELS, ELECTROPHYSIOLOGY, IMMUNOCHEMISTRY, CYTOLOGY, HISTOCHEMISTRY, PERIPHERAL NERVOUS SYSTEM.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE