Accession Number : ADA321553

Title :   Neural Responses to Injury: Prevention, Protection, and Repair. Volume 4: Neurochemical Protection of the Brain, Neural Plasticity and Repair.

Descriptive Note : Annual technical rept. 20 Sep 94-19 Sep 95,

Corporate Author : LOUISIANA STATE UNIV MEDICAL CENTER NEW ORLEANS

Personal Author(s) : Bazan, Nicolas G.

PDF Url : ADA321553

Report Date : 1995

Pagination or Media Count : 122

Abstract : The biologically active phospholipid platelet activating factor (1-O-alkyl-sn-glycero-3- phosphocholine, PAF), a phospholipase A2 (PLA2) product, is involved in excitatory neurotransmitter (i. e. Glutamate) release and synaptic plasticity (Bazan et al. ,1993). Several physiological roles of PAF have been described, such as its ability to stimulate PC 12 cell sprouting when present at low concentrations (Kornecki and Ehrlich, 1988), its stimulatory effect on glutamate release (Clark et al., 1992), and its involvement in the development of glutamate-mediated long-term potentiation (Del Cerro et al., 1990; Arai and Lynch, 1992; Wieraszko et al., 1993; Bazan et al., 1993), considered as a model of mechanisms underlying memory and learning in the brain (Teyler and DiScenna, 1984). As a consequence of neuronal cell injury, processes that normally modulate synaptic function are overactivated, leading to the accumulation of membrane lipid-derived second messengers such as 20:4 and PAF. These mediators of the cellular response to injury can lead to repair and/or to further cell damage and death (Bazan, 1994), depending upon their cellular origin and degree of neuronal activity impairment.

Descriptors :   *GLUTAMIC ACID, *NERVOUS SYSTEM, *NERVE CELLS, *NEUROCHEMISTRY, *WOUNDS AND INJURIES, *SYNAPSE, DAMAGE, BRAIN, LOW LEVEL, CONCENTRATION(COMPOSITION), PLASTIC PROPERTIES, PHYSIOLOGY, SALTS, ACCUMULATION, DEATH, CELLS(BIOLOGY), NEUROTRANSMITTERS, LEARNING.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE