Accession Number : ADA321591

Title :   Genetic Immunization for Lentiviral Immunodeficiency Virus Infection and Disease.

Descriptive Note : Annual rept. 30 Sep 95-29 Sep 96,

Corporate Author : CALIFORNIA UNIV DAVIS

Personal Author(s) : Gardner, Murray B.

PDF Url : ADA321591

Report Date : OCT 1996

Pagination or Media Count : 188

Abstract : In year two of this project we have developed and characterized four novel SIV envelope expression vectors and one vector expressing both envelope and core components for genetic immunization of rhesus monkeys. Experiments using test antigens to determine optimum DNA vaccine parameters are near completion. Beginning in January 1997 we will test one or more of these SIV DNA vaccines for protection against SIV challenge infection via systemic (IV) and mucosal (vaginal) routes of administration. As a potential secondary challenge, should the vaccinated monkeys be protected against homologous SIV, we have developed a pathogenic SIV/HIV (SHIV) envelope recombinant. Cytokine profiles of acutely infected monkeys have been characterized and a large number of rhesus cytokine, B-chemokine and chemokine receptor genes have been cloned, sequenced and recombinant molecules prepared for possible use as immune modulators or adjuvants.

Descriptors :   *MOLECULES, *GENES, *INFECTIOUS DISEASES, *IMMUNIZATION, *VACCINES, TEST AND EVALUATION, OPTIMIZATION, CORES, PARAMETERS, DEOXYRIBONUCLEIC ACIDS, CLONES, IMMUNITY, HUMAN IMMUNODEFICIENCY VIRUSES, ENVELOPE(SPACE), GENETICS, ANTIGENS, SENSE ORGANS, RHESUS MONKEYS, MONKEYS.

Subject Categories : Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE