Accession Number : ADA321776

Title :   Estrogen Responsive Breast Cancer Growth Regulation.

Descriptive Note : Annual rept. 15 Sep 95-14 Sep 96,

Corporate Author : TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON

Personal Author(s) : Sirbasku, David A.

PDF Url : ADA321776

Report Date : OCT 1996

Pagination or Media Count : 23

Abstract : The overall goal of this program was to characterize the serum factor(s) which regulated steroid hormone dependent human breast cancer cell growth. This included an identification of the molecule(s) and studies to establish the endocrine physiology of the regulator(s) as well as partial characterization of the receptors mediating serum factor action. We have discovered that two plasma glycoproteins, SHBG Type II and CBG, are negative regulators (i. e. inhibitors) of estrogen receptor positive (ER+) and progesterone receptor positive (PR+) breast cancer cell growth, respectively, and that autonomous (ER- and PR-) breast cancer cells are not inhibited by these glycoproteins. The new form of sex hormone binding globulin has been designated SHBG Type II. It has not previously been identified or characterized from any source. The discovery of a new regulatory role for CBG in breast cancer growth may provide our first molecular link between increased stress and an elevated risk of breast cancer.

Descriptors :   *HORMONES, *GROWTH(PHYSIOLOGY), *ESTROGENS, *BREAST CANCER, CONTROL, RISK, PLASMAS(PHYSICS), GLYCOPROTEINS, REGULATORS, PHYSIOLOGY, BLOOD SERUM, CELLS(BIOLOGY), SENSE ORGANS, SEX, GLOBULINS, STEROIDS, PROGESTERONE, ENDOCRINOLOGY.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE