Accession Number : ADA321826

Title :   Dermal Toxicity Evaluation of Neutralized Chemical Agent Identification Sets (CAIS) with an Overview of the Dermal Toxicity of Vesicant Agents and their Degradation Products.

Descriptive Note : Final rept. Jan-Sep 95,

Corporate Author : EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUNDMD

Personal Author(s) : Olajos, Eugene J. ; Cameron, Kenneth P. ; Way, Ruth A. ; Manthei, James H. ; Heitkamp, Dale H.

PDF Url : ADA321826

Report Date : OCT 1996

Pagination or Media Count : 182

Abstract : Acute dermal toxicity (limit test) and skin irritation studies were conducted in New Zealand white rabbits to ascertain the systemic toxicity and skin-injury potential of chemically-neutralized Chemical Agent Identification Sets (CAIS). Studies also included the assessment of oxidant/solvent systems and solvent induced toxicity. The toxicity limit test consisted of a 24-hr occluded exposure to 1.0 ml/kg of 'test article.' Dermal irritation studies were based on a 4-hr occluded exposure to 0.5 ml of 'test article.' Chemical neutralization of CAIS resulted in complex product solutions (wastestreams) containing ppm levels of agent and an array of degradation products. Findings from the skin irritation testing of wastestreams and oxidant/solvent systems indicate that wastestream-induced skin effects (edema and erythema) were equivalent to or less in severity than the skin effects produced by exposure to oxidant/solvent systems. Systemic effects were not observed in 4/5 wastestream-exposed groups; however, 2/5 wastestream-treated groups exhibited systemic effects. Lethality was noted in only 1/5 wastestream-treated groups. Limit test data indicate that agents (HD, HN, or L) were destroyed by reaction with oxidant to less toxic materials.

Descriptors :   *TOXICITY, *CHEMICAL AGENTS, *SKIN(ANATOMY), TEST AND EVALUATION, EXPERIMENTAL DATA, DEGRADATION, MATERIALS, ARRAYS, LIMITATIONS, OXIDIZERS, SOLVENTS, LETHALITY, CHEMICAL ANALYSIS, RABBITS, WHITE(COLOR), VESICANTS, EDEMA, ERYTHEMA, IRRITATION, NEW ZEALAND, SKIN TESTS.

Subject Categories : Anatomy and Physiology
      Toxicology
      Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE