Accession Number : ADA321911

Title :   MR Microscope for Use in Histology.

Descriptive Note : Final rept. 21 Aug 95-20 Aug 96,

Corporate Author : CONDUCTUS INC SUNNYVALE CA

Personal Author(s) : Withers, R. S. ; Johnson, G. A. ; Hurlston, S. E.

PDF Url : ADA321911

Report Date : SEP 1996

Pagination or Media Count : 28

Abstract : The long-term goal of this project is to develop a magnetic resonance microscope (MRM) suitable for providing sufficiently rapid assessment of tissue pathology to guide surgery. In this first phase of the project, a feasibility study has been performed. Sensitivity is the key technical issue to developing a practical MRM for clinical applications, so two issues that are crucial to sensitivity have been evaluated: the strength of the polarizing field and the design of the RF coil. The optimal strength of the polarizing field was evaluated based on the contrast to noise ratio (CNR) of a T1 weighted image. For a wide range of relaxation parameters there was a pronounced peak in the CNR at fairly low field. The choice of such a magnetic field would dramatically reduce the cost and size of the final instrument. The performance of HTS and copper RF coils was compared in a 2.0 T MRI system. Even under conditions that were far from ideal, a factor of two improvement in sensitivity was obtained with HTS coils. The results point to a new strategy for providing high contrast and resolution in a relatively inexpensive, compact instrument.

Descriptors :   *MICROSCOPES, *HISTOLOGY, *MAGNETIC RESONANCE IMAGING, COILS, MAGNETIC FIELDS, POLARIZATION, CONTRAST, TISSUES(BIOLOGY), NUCLEAR MAGNETIC RESONANCE, PARAMETERS, SUPERCONDUCTORS, CLINICAL MEDICINE, SENSITIVITY, HIGH RESOLUTION, STRENGTH(MECHANICS), COSTS, FEASIBILITY STUDIES, COPPER, INSTRUMENTATION, RELAXATION, PATHOLOGY, HIGH TEMPERATURE SUPERCONDUCTORS, SURGERY, RADIOFREQUENCY.

Subject Categories : Electricity and Magnetism
      Optics
      Nuclear Physics & Elementary Particle Physics
      Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE