Accession Number : ADA321915

Title :   Improvement of Cultured Keratinocyte Grafts for Burn Wounds.

Descriptive Note : Annual rept. 31 Dec 95-30 Dec 96,

Corporate Author : NORTH CAROLINA UNIV AT CHAPEL HILL

Personal Author(s) : Meyer, Anthony A.

PDF Url : ADA321915

Report Date : JAN 1997

Pagination or Media Count : 65

Abstract : During the first year of grant support all components in the Statement of Work scheduled for year one have been completed, with one still in progress. The results have demonstrated that cultured keratinocyte allografts are less immunogenic in burned animals as measured by priming for second-set rejection and cytotoxic lymphocytes. Burn injury impairs expression of alloantigen on keratinocyte allograft as one mechanism of this effect. A second mechanism that effects the response is an increase in cytokine in the burn wound and distant normal tissue after burn injury. Notably, cultured keratinocyte allografts deficient in Class II histocompatability antigen are significantly less immunogenic, especially after burn injury, and may provide a means to produce universal donor keratinocytes.

Descriptors :   *LYMPHOCYTES, *BURNS(INJURIES), ANIMALS, CYTOTOXINS, SKIN GRAFTS, KERATINIZATION.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE