Accession Number : ADA322065

Title :   The Potential Role of Calcitriol Analogs in the Management of Breast Cancer.

Descriptive Note : Final rept. 1 Sep 94-30 Sep 96,

Corporate Author : CALIFORNIA UNIV SAN FRANCISCO

Personal Author(s) : Bikle, Daniel D.

PDF Url : ADA322065

Report Date : OCT 1996

Pagination or Media Count : 21

Abstract : Breast cancer is the second leading cause of cancer deaths among females and a leading cause of death of all middle age women in the United States. Epidemiologic evidence suggests a role for vitamin D deficiency in the development of breast cancer. Moreover, vitamin D receptors have been found in most breast cancers, and their presence appears to be a favorable prognostic sign. While much clinical focus has been given to the vitamin A related retinoids, little is known about the role for vitamin D in the development of breast cancer although vitamin D and its active metabolites and analogs represent a class of compounds which at the molecular and cellular level have strong similarities to the vitamin A metabolites and analogs. With the development of potent but non hypercalcemic analogs of vitamin D, the potential role of vitamin D in the etiology and treatment of breast cancer can now be tested both in vitro and in vivo. In the past decade, a number of tissues have been found to contain receptors for the active vitamin D metabolite, 1,25(OH)2 D, and to respond to this hormone with a change in function.

Descriptors :   *VITAMIN D, *CHEMICAL ANALOGS, *BREAST CANCER, CALCIUM, HORMONES, TISSUES(BIOLOGY), MOLECULAR STATES, PEPTIDES, IN VITRO ANALYSIS, ETIOLOGY, IN VIVO ANALYSIS, CELLS(BIOLOGY), EPIDEMIOLOGY, RECEPTOR SITES(PHYSIOLOGY), AMINO ACIDS, FEMALES, METABOLITES, INSULIN, HEMATOPOIETIC CELLS, ANTIMETABOLITES, VITAMIN A, ESTROGENS.

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE