Accession Number : ADA322196

Title :   Biological Specimen Bank to Enhance Population Based Studies of Inherited Breast Cancer Genes.

Descriptive Note : Annual rept. 30 Sep 95-29 Sep 96,

Corporate Author : DANA-FARBER CANCER INST BOSTON MA

Personal Author(s) : Li, Frederick P.

PDF Url : ADA322196

Report Date : OCT 1996

Pagination or Media Count : 65

Abstract : The technical objectives of this infrastructure enhancement project are to establish a population-based biological specimen and data bank on 225 women with invasive breast cancer, aged 35 and under. This new resource will be available to multiple investigators to identify and determine the frequency of inherited gene alterations in p53, BRCA1 and additional inherited breast cancer susceptibility genes, and studies of gene-environmental interactions. Our cases will help refine estimates of germinal mutation frequency among young patients who have no family history of breast cancer. Work is on schedule so that 225 young cases will be ascertained over 36 months through the tumor incidence registries in Connecticut, Massachusetts and 7 regions in California. Demographic, epidemiologic and family history data are being collected, paraffin-fixed tumor tissue retrieved, and fresh blood specimens will be processed to produce genomic DNA, a plasma specimen, and viably frozen cells. A computerized file of the epidemiologic data and specimen data will be made accessible to all researchers via the Internet.

Descriptors :   *GENES, *TISSUE BANKS, *BREAST CANCER, DATA BASES, FREQUENCY, DEMOGRAPHY, NEOPLASMS, POPULATION, DEOXYRIBONUCLEIC ACIDS, MUTATIONS, CHROMOSOMES, FREEZING, HISTORY, CALIFORNIA, CONNECTICUT, CELLS(BIOLOGY), WOMEN, INTERNET, EPIDEMIOLOGY, MASSACHUSETTS, HISTOLOGICAL TECHNIQUES, GERM CELLS, INFRASTRUCTURE.

Subject Categories : Information Science
      Medicine and Medical Research
      Computer Programming and Software

Distribution Statement : APPROVED FOR PUBLIC RELEASE