Accession Number : ADA322200

Title :   Cyclic AMP Modulation of Estrogen-Induced Effects: A Novel Mechanism for Hormonal Resistance in Breast Cancer.

Descriptive Note : Annual rept. 1 Oct 95-30 Sep 96,

Corporate Author : ILLINOIS UNIV AT URBANA

Personal Author(s) : Katzenellenbogen, Benita S.

PDF Url : ADA322200

Report Date : OCT 1996

Pagination or Media Count : 106

Abstract : This research is aimed at elucidating why breast cancer cells become resistant to antiestrogen treatment. Antiestrogens are used widely in the treatment of breast cancer, but development of resistance and patient relapse is a significant problem. The antiestrogen tamoxifen is the most widely prescribed drug for breast cancer treatment and it is usually considered the treatment of choice for the endocrine therapy of breast cancer because of its effectiveness, ease of use, and minimal side effects. In these studies we are using several model human breast cancer cell systems that differ in their sensitivity and resistance to tamoxifen, and we are investigating a novel mechanism and hypothesis that may explain antiestrogen resistance, namely the stimulation of adenylate cyclase by antiestrogens with increases in intracellular cAMP, augmentation of antiestrogen agonist character, and reduced effectiveness of antiestrogens as estrogen antagonists.

Descriptors :   *HORMONES, *MODULATION, *ESTROGENS, *BREAST CANCER, STIMULATION(PHYSIOLOGY), MODELS, RESISTANCE, ENZYMES, PHYSIOLOGICAL EFFECTS, DRUGS, CELLS(BIOLOGY), CYCLIC COMPOUNDS, PHARMACOLOGICAL ANTAGONISTS, ENZYME PRECURSORS, ADENOSINE PHOSPHATES, ADENYL CYCLASE, ENDOCRINOLOGY.

Subject Categories : Biochemistry
      Medicine and Medical Research
      Pharmacology
      Computer Programming and Software

Distribution Statement : APPROVED FOR PUBLIC RELEASE