Accession Number : ADA322215

Title :   Defining the Smallest Common Region of Chromosome 17p that is Deleted in Sporadic Breast Tumors.

Descriptive Note : Annual rept. 1 Oct 95-30 Sep 96,

Corporate Author : MICHIGAN UNIV ANN ARBOR

Personal Author(s) : Wicha, Max S. ; Merajver, Sofia D.

PDF Url : ADA322215

Report Date : OCT 1996

Pagination or Media Count : 9

Abstract : Germline mutations in breast cancer susceptibility genes account for 8% of all breast cancer cases. BRCA1 on 17q12 and BRCA2 on 13q12-13 are implicated in 50%-60% of breast cancer families, and they are both likely to also have an impact in sporadic breast cancer cases. Recently defined loci on chromosome 8p 12-22 are frequently lost in sporadic breast cancers and there is evidence for families with linkage to these loci. We propose to ascertain 8 ethically diverse (non-Caucasian) families linked to putative BRCA3 loci on chromosome 8p, and to investigate whether a recently isolated prostate cancer metastases suppressor gene, KAII, is involved in the genetic alterations of inflammatory breast cancer, a particularly aggressive form of breast cancer which accounts for 15% of all cases.

Descriptors :   *CHROMOSOMES, *GENES, *BREAST CANCER, POSITION(LOCATION), NEOPLASMS, MUTATIONS, REGIONS, ETHNIC GROUPS, FAMILIES(HUMAN), MAMMARY GLANDS, SUPPRESSORS, PROSTATE GLAND, METASTASIS.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE