Accession Number : ADA322232

Title :   Vasopressin Gene-Related Products in the Management of Breast Cancer.

Descriptive Note : Annual rept. 1 Oct 95-30 Sep 96,

Corporate Author : DARTMOUTH COLL HANOVER NH

Personal Author(s) : North, William G.

PDF Url : ADA322232

Report Date : OCT 1996

Pagination or Media Count : 38

Abstract : The overall objective of this project is to improve the detection and treatment of breast cancer by evaluating vasopressin gene-related products as tumor marker substances in hyperplastic breast disease, by characterizing the nature and regulation of the vasopressin gene and its products in breast cancer, and by determining the potential usefulness of vasopressin gene-related products on tumor membranes as targets for immunotherapy. It seeks to test the hypothesis that all breast tumors produce vasopressin as an autocrine growth factor, in situ, and that this property can be effectively utilized not only to elucidate the pathobiology of this cancer, but also to identify precancerous tissue and develop more successful treatments.

Descriptors :   *PITUITARY HORMONES, *BREAST CANCER, TISSUES(BIOLOGY), DETECTION, NEOPLASMS, GENES, IMMUNIZATION, RECEPTOR SITES(PHYSIOLOGY), MAMMARY GLANDS, GROWTH(PHYSIOLOGY).

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE