Accession Number : ADA322233

Title :   Role of Accessory Molecule(s) in Endotoxin-Endothelial Interactions and Endothelial Barrier Dysfunction.

Descriptive Note : Annual rept. 1 Jun 95-31 May 96,

Corporate Author : MARYLAND UNIV BALTIMORE SCHOOL OF MEDICINE

Personal Author(s) : Goldblum, Simson E.

PDF Url : ADA322233

Report Date : JUL 1996

Pagination or Media Count : 57

Abstract : This grant has been renegotiated and the new technical objectives are: (1) To determine whether LPS induces tyrosine phosphorylation of endothelial cell proteins that can be coupled to changes in barrier function. (2) To determine whether this LPS-induced endothelial intercellular gap formation and barrier dysfunction is due to zonula adherens and/or focal adhesion disassembly. (3) To determine which protein substrates are the targets of LPS-induced tyrosine phosphorylation.

Descriptors :   *BARRIERS, *DYSFUNCTION, *ENDOTOXINS, *ENDOTHELIUM, COUPLING(INTERACTION), FUNCTIONS, INTERACTIONS, PROTEINS, ADHESION, SUBSTRATES, CELLS(BIOLOGY), TYROSINE, DISASSEMBLY, PHOSPHORYLATION.

Subject Categories : Anatomy and Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE