Accession Number : ADA322340

Title :   P53 Mutation Profiles in Premenopausal Versus Postmenopausal Breast Cancer in a Stationary Population.

Descriptive Note : Annual rept. 1 Sep 95-31 Aug 96,

Corporate Author : SALK INST FOR BIOLOGICAL STUDIES LA JOLLA CA

Personal Author(s) : Yu, BaoFa

PDF Url : ADA322340

Report Date : SEP 1996

Pagination or Media Count : 21

Abstract : One major clinical problem is how to predict which patients will relapse and metastasis. Recently, Dr. Yu has found that loss of the pl6 gene is directly associated with the loss of cancer cell adhesion, the first step for metastasis. We aim to test our hypothesis that (1) the inactivation of pl6 gene is higher in the metastatic cancers than non-metastatic cancers; (2) the adhesion strength of pl6+ cancer cells is higher than that of pl6 cancer cells; (3) the incidence of metastasis in vivo is higher in pl6 cancer cells than pl6+ cancer cells and (4) transfection of wildtype pl6 cDNA can reduce metastasis in vivo. This study will help us to elucidate whether the pl6 gene plays a role in the metastasis of cancers, and to screen and mark cancer metastasis potential, which will be beneficial in the early detection, prevention, and gene therapy of cancer metastasis.

Descriptors :   *MUTATIONS, *ESTROUS CYCLE, *BREAST CANCER, DETECTION, STRENGTH(PHYSIOLOGY), ADHESION, CLINICAL MEDICINE, POPULATION, DEOXYRIBONUCLEIC ACIDS, STATIONARY, THERAPY, GENES, IN VIVO ANALYSIS, CELLS(BIOLOGY), METASTASIS.

Subject Categories : Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE