Accession Number : ADA322371

Title :   The Inhalation Toxicity of Sodium Acid Sulfate Mist at 75 MG/M3 in Animals.

Corporate Author : TECHNICAL INFORMATION SERVICE (AEC) OAK RIDGE TN

Personal Author(s) : Sprague, George F. ; Doran, Edward ; Scott, James K. ; Stokinger, H. E.

PDF Url : ADA322371

Report Date : 1949

Pagination or Media Count : 6

Abstract : Because the current literature contains reports that throw doubt on the toxicity of beryllium per Se and point instead to the putative toxicity of the acidic ions of its salts, especially sulfate and fluoride, an inhalation study of sodium acid sulfate mist was performed to determine whether the sulfate ion had a toxicity comparable to that of beryllium sulfate. Accordingly, an inhalation experiment was performed in which the conditions of exposure duplicated those in which beryllium sulfate had been used as the toxic agent except that in the present study, sodium acid sulfate solution, with a pit of 1.7, had been substituted for the beryllium salt solution. Twenty guinea pigs and 10 rats were exposed daily for more than 2 weeks to 75 mg/m3 of the acid sulfate salt. This treatment produced no general weight loss in either species. In one rat and 2 guinea pigs that died from causes apparently unrelated to the exposure, however, some weight loss occurred. No lesions were observed in any animal that could be attributed to the exposure of the NaHSO4 mist, either in small groups of animals killed 10 days from the start of exposure or in the remainder of the exposed animals killed 16 days after the termination of the exposure.

Descriptors :   *TOXICITY, *BERYLLIUM, *SULFATES, IONS, EXPOSURE(GENERAL), RATS, SOLUTIONS(MIXTURES), SODIUM, SALTS, WEIGHT REDUCTION, LESIONS, ACIDS, INHALATION, MIST, GUINEA PIGS, SODIUM SULFATES.

Subject Categories : Toxicology
      Metallurgy and Metallography

Distribution Statement : APPROVED FOR PUBLIC RELEASE