Accession Number : ADA322429

Title :   A New Generic Method for the Production of Protein-Based Inhibitors of Proteins Involved in Cancer Metastasis.

Descriptive Note : Annual rept. 1 Aug 95-31 Jul 96,

Corporate Author : NORTH CAROLINA UNIV AT CHAPEL HILL

Personal Author(s) : Edgell, Marshall H.

PDF Url : ADA322429

Report Date : AUG 1996

Pagination or Media Count : 36

Abstract : Our objectives are to learn how to efficiently build proteins which will act as inhibitors to proteins involved in cancer metastasis. It is our expectation that such proteins can be constructed so as to be very specific for the desired target. While such inhibitors might be useful themselves as therapeutic molecules, they will certainly be useful as probes to define the issues associated with inactivating the target proteins; both the primary effects and side-effects. The approach to be used in this project is to combine molecular genetics and protein biophysics to redirect to the target of interest the activity of a pre-existing protein which will serve as a framework onto which to mount the desired modifications. Molecular genetics will be used to extend the reach of traditional protein engineering.

Descriptors :   *PROTEINS, *INHIBITORS, *METASTASIS, *BREAST CANCER, STRATEGY, PRODUCTION, MOLECULES, STRUCTURAL PROPERTIES, TARGETS, VARIATIONS, THERAPY, MOLECULAR BIOLOGY, INHIBITION, LIBRARIES, SELECTION, GENETICS, BIOPHYSICS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE