Accession Number : ADA322662

Title :   Investigations in Fish Control. 98. History of Acute Toxicity with Fish, 1863-1987.

Corporate Author : FISH AND WILDLIFE SERVICE COLUMBIA MO NATIONAL FISHERIES CONTAMINANT RESEARCH CENTER

Personal Author(s) : Hunn, Joseph B.

PDF Url : ADA322662

Report Date : 1989

Pagination or Media Count : 16

Abstract : Acute toxicity tests with fish were first reported in 1863. Test methodology developed slowly before World War II, during the period when the goldfish (Carassius auratus) was the recommended test animal. After the war, considerable effort was made to standardize test methods. A standardized method was published in 1960, refined in 1975, and updated in 1980. The primary use of the static acute toxicity test is to determine the median concentrations of chemicals that are lethal to aquatic organisms. Other applications include establishing the half-life of the biological activity of chemicals, evaluating the toxicity of mixtures of chemicals, and developing quantitative structure activity relations used in predicting the toxicity of particular groups of chemicals.

Descriptors :   *TOXICITY, *FISHES, CONTROL, QUANTITATIVE ANALYSIS, CHEMICAL CONTAMINATION, TEST METHODS, HISTORY, CONCENTRATION(COMPOSITION), STANDARDIZATION, LETHALITY, AQUATIC ORGANISMS, HALF LIFE.

Subject Categories : Biology
      Toxicology
      Physical Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE