Accession Number : ADA322991

Title :   Effect of a Soy Dietary Supplement on Menopausal Symptoms and Hormones in Women at High Risk of Breast Cancer.

Descriptive Note : Annual rept. 30 Sep 95-29 Sep 96,

Corporate Author : TUFTS UNIV BOSTON MA SCHOOL OF MEDICINE

Personal Author(s) : Woods, Margo N.

PDF Url : ADA322991

Report Date : OCT 1996

Pagination or Media Count : 28

Abstract : Women at high risk for breast cancer who are experiencing menopausal symptoms of hot flashes are being recruited for our study in Boston and New York. Breast Health Clinics and Women's Clinics are being used to inform women about the study. In Boston, we have recently used radio advertising to locate our study population which has been highly successful. Women with => 5 symptoms per day are randomized, using a double-blind, cross-over study design, to receive either a placebo bar or soy supplement bar for 3 months with one month of wash-out between protocols. Two blood samples are taken at baseline and during the last week of each of the two 3-month study periods. Serum levels of estrone, estradiol, estrone-sulfate, androstenedione, and follicle stimulating hormone are measured. Subjects keep a daily symptoms diary for the entire seven month study. A matched group of control women with <2 hot flashes/day are also being studied. This study proposes to determine: (1) if a dietary soy supplement (containing 45 mg of phytoestrogens) relieves menopausal hot flash symptoms, (2) if a dietary soy supplement bar affects hormone levels, and (3) the relationship between menopausal symptoms and hormone levels.

Descriptors :   *HORMONES, *CLINICAL MEDICINE, *SIGNS AND SYMPTOMS, *DIET, *NUTRITION, *MAMMARY GLANDS, *BREAST CANCER, CONTROL, HIGH RATE, HEALTH, HIGH TEMPERATURE, NEW YORK, POPULATION, SAMPLING, PLACEBOS, WOMEN, DAILY OCCURRENCE, BLOOD, FLASHES, SOY PROTEIN.

Subject Categories : Medicine and Medical Research
      Food, Food Service and Nutrition
      Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE