Accession Number : ADA323200
Title : Preparation of Chemicals and Bulk Drug Substances for the U.S. Army Drug Development Program.
Descriptive Note : Annual rept. 1 Dec 95-30 Nov 96,
Corporate Author : ASH STEVENS INC DETROIT MI
Personal Author(s) : Blumbergs, Peter
PDF Url : ADA323200
Report Date : DEC 1996
Pagination or Media Count : 126
Abstract : The purpose of the contract is to provide a variety of high purity chemicals and bulk drug substances for the U.S. Army Medical R & D Command. During the 12 months, eighteen assignments were completed. Compounds prepared and submitted include the antimalarial WR 238605, one metabolite of WR 238605, four potential metabolites of WR 242511, four pyridinecarbamates, one substituted benzenesulfonamide, two benzenesulfonyl chlorides, and a 3-deazapurine. In addition, racemic desbutylhalofantrine and WR 242511 were resolved to provide samples of the optically active enantiomers.
Descriptors : *CHEMICALS, *BULK MATERIALS, *DRUGS, OPTICAL PROPERTIES, BENZENE, HIGH RATE, PREPARATION, SYNTHESIS, RESOLUTION, PURITY, CHLORIDES, ARMY, METABOLITES, PYRIDINES, ANTIMALARIALS, CARBAMATES, SULFONYL RADICALS, SULFONAMIDES.
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE