Accession Number : ADA323200

Title :   Preparation of Chemicals and Bulk Drug Substances for the U.S. Army Drug Development Program.

Descriptive Note : Annual rept. 1 Dec 95-30 Nov 96,

Corporate Author : ASH STEVENS INC DETROIT MI

Personal Author(s) : Blumbergs, Peter

PDF Url : ADA323200

Report Date : DEC 1996

Pagination or Media Count : 126

Abstract : The purpose of the contract is to provide a variety of high purity chemicals and bulk drug substances for the U.S. Army Medical R & D Command. During the 12 months, eighteen assignments were completed. Compounds prepared and submitted include the antimalarial WR 238605, one metabolite of WR 238605, four potential metabolites of WR 242511, four pyridinecarbamates, one substituted benzenesulfonamide, two benzenesulfonyl chlorides, and a 3-deazapurine. In addition, racemic desbutylhalofantrine and WR 242511 were resolved to provide samples of the optically active enantiomers.

Descriptors :   *CHEMICALS, *BULK MATERIALS, *DRUGS, OPTICAL PROPERTIES, BENZENE, HIGH RATE, PREPARATION, SYNTHESIS, RESOLUTION, PURITY, CHLORIDES, ARMY, METABOLITES, PYRIDINES, ANTIMALARIALS, CARBAMATES, SULFONYL RADICALS, SULFONAMIDES.

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE