Accession Number : ADA323555

Title :   Development of New Approaches for Breast Cancer Therapy and Diagnosis Based on Angiogenesis.

Descriptive Note : Annual rept. 30 Sep 95-29 Sep 96,

Corporate Author : CHILDREN'S HOSPITAL CORP BOSTON MA

Personal Author(s) : Ingber, Donald

PDF Url : ADA323555

Report Date : OCT 1996

Pagination or Media Count : 13

Abstract : This project focuses on angiogenesis, the growth of new blood capillaries, as a potential target for breast cancer therapy and diagnosis. Our approach is based on our past demonstration that many of the signal transducing molecules that mediate the effects of angiogenic mitogens and extracellular matrix molecules are concentrated within specialized cell adhesion sites, known as the focal adhesion complexes (FACs). Over the past year, we demonstrated that a known angiogenesis inhibitor, TNP-470, inhibits the activity of ppl25FAK, a tyrosine protein kinase that is also a major structural component of the FAC. We also began to develop and screen monoclonal antibodies using isolated FACs as an immunogen. Production of these antibodies and identification of molecules that mediate growth modulation in capillary cells should facilitate development of new angiogenesis inhibitors as well as alternative methods for breast cancer diagnosis.

Descriptors :   *MONOCLONAL ANTIBODIES, *DIAGNOSTIC AGENTS, *BREAST CANCER, INHIBITORS, TYROSINE, GROWTH(PHYSIOLOGY), PHOSPHORYLATION, IMMUNOGENS, CAPILLARIES(ANATOMY), PHOSPHORUS TRANSFERASES.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE