Accession Number : ADA323648

Title :   Genetic Abnormalities in Breast Cancer Tumors and Relationships to Environmental and Genetic Risk Factors Using Twins.

Descriptive Note : Annual rept. 1 Oct 95-30 Sep 96,

Corporate Author : UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES

Personal Author(s) : Mack, Thomas M.

PDF Url : ADA323648

Report Date : OCT 1996

Pagination or Media Count : 19

Abstract : Little is known about factors that produce genetic abnormalities in breast tumors; germline mutations explain only a few cases. Specifically we will address the following issues in this study: (1) Are genetically similar tumors more likely to occur among identical twins than among fraternal twins?; (2) Do environmental factors predispose to concordance or discordance of genetic abnormalities?; (3) Do fraternal twins, concordant for environmental exposures, tend to be discordant for genetic abnormalities, suggesting that other predisposing genetic factors that can be identified?; (4) Among identical twins discordant for disease, are specific environmental factors more related to tumors with a genetic abnormality than those without?

Descriptors :   *GENETICS, *ABNORMALITIES, *BREAST CANCER, ENVIRONMENTS, RISK, NEOPLASMS, MUTATIONS, SEQUENCES, EXPOSURE(PHYSIOLOGY), EPIDEMIOLOGY, RECEPTOR SITES(PHYSIOLOGY), MAMMARY GLANDS, PROGESTERONE, GERM CELLS, ESTROGENS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE