Accession Number : ADA323762

Title :   Cell-Matrix Interactions in Breast Cancer Cells.

Descriptive Note : Annual rept. 15 Aug 95-14 Aug 96,

Corporate Author : NORTHWESTERN UNIV EVANSTON IL

Personal Author(s) : Jones, Jonathan C.

PDF Url : ADA323762

Report Date : SEP 1996

Pagination or Media Count : 77

Abstract : Modulation in adhesion of tumor cells compared with their normal counterparts plays an important role in development of invasive potential. Our application, as funded, concerns the fate of certain epithelial cell-matrix connectors called hemidesmosomes which are involved in anchoring breast epithelial cells to underlying matrix. The following were the set of tasks funded by the US Army in 1994. Task (1) Immunochemical characterization of hemidesmosome components in normal and tumor breast tissue and their cultured cell counterparts Task (2) Molecular analyses where message levels of HD proteins will be determined (complimentary to task 1). Task (3) Electron microscopic evaluation of normal and tumor material Task (4) Cell assays in matrigel

Descriptors :   *INTERACTIONS, *ADHESION, *CELLS(BIOLOGY), *BREAST CANCER, EPITHELIUM, TISSUES(BIOLOGY), PROTEINS, NEOPLASMS, ELECTRON MICROSCOPY, ANTIBODIES, MOLECULAR BIOLOGY, MODULATION, ASSAYING, RECEPTOR SITES(PHYSIOLOGY), MAMMARY GLANDS, PHOSPHORYLATION, MORPHOGENESIS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE