Accession Number : ADA323763
Title : Breast Cancer Metastasis: Prognosis and Monitoring of Metastatic Disease.
Descriptive Note : Annual rept. 23 Sep 95-22 Sep 96,
Corporate Author : M D ANDERSON CANCER CENTER HOUSTON TX
Personal Author(s) : Boyd, Douglas
PDF Url : ADA323763
Report Date : OCT 1996
Pagination or Media Count : 11
Abstract : During the past several years we have conducted extensive studies on the role of degradative enzymes in the invasion and metastasis of breast cancers. We found that only a few enzymes were implicated in the invasion of human breast cancer cells, such as heparanase and type IV collagenolytic metalloproteinases. The major purposes of the proposal are: (1) Develop prognostic tests for breast cancer invasion and metastasis-associated degradative enzymes. (2) Develop assays to monitor the appearance of metastatic disease in breast cancer patients by detecting the appearance of metastasis- associated degradative enzymes in blood. (3) Develop assays to monitor the treatment of metastatic disease in breast cancer patients by following the levels of metastasis- associated degradative enzymes in blood.
Descriptors : *METASTASIS, *BREAST CANCER, TISSUES(BIOLOGY), MONITORING, HUMANS, PEPTIDES, ENZYMES, DISEASES, ANTIBODIES, PATIENTS, IMMUNOLOGY, BLOOD SERUM, CELLS(BIOLOGY), IMMUNOASSAY, GOATS, AMINO ACIDS, CHEMOTHERAPY, BLOOD PLASMA, COLLAGEN, RADIOTHERAPY.
Subject Categories : Biochemistry
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE