Accession Number : ADA323763

Title :   Breast Cancer Metastasis: Prognosis and Monitoring of Metastatic Disease.

Descriptive Note : Annual rept. 23 Sep 95-22 Sep 96,

Corporate Author : M D ANDERSON CANCER CENTER HOUSTON TX

Personal Author(s) : Boyd, Douglas

PDF Url : ADA323763

Report Date : OCT 1996

Pagination or Media Count : 11

Abstract : During the past several years we have conducted extensive studies on the role of degradative enzymes in the invasion and metastasis of breast cancers. We found that only a few enzymes were implicated in the invasion of human breast cancer cells, such as heparanase and type IV collagenolytic metalloproteinases. The major purposes of the proposal are: (1) Develop prognostic tests for breast cancer invasion and metastasis-associated degradative enzymes. (2) Develop assays to monitor the appearance of metastatic disease in breast cancer patients by detecting the appearance of metastasis- associated degradative enzymes in blood. (3) Develop assays to monitor the treatment of metastatic disease in breast cancer patients by following the levels of metastasis- associated degradative enzymes in blood.

Descriptors :   *METASTASIS, *BREAST CANCER, TISSUES(BIOLOGY), MONITORING, HUMANS, PEPTIDES, ENZYMES, DISEASES, ANTIBODIES, PATIENTS, IMMUNOLOGY, BLOOD SERUM, CELLS(BIOLOGY), IMMUNOASSAY, GOATS, AMINO ACIDS, CHEMOTHERAPY, BLOOD PLASMA, COLLAGEN, RADIOTHERAPY.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE