Accession Number : ADA323849

Title :   Symposium: The Exploration of Sequence Space Selecting Functions Molecules from Combinatorial Libraries.

Descriptive Note : Final rept.,

Corporate Author : INDIANA UNIV AT BLOOMINGTON

Personal Author(s) : Ellington, Andrew D.

PDF Url : ADA323849

Report Date : FEB 1997

Pagination or Media Count : 6

Abstract : The ONR provided funding for a conference that was designed to explore interactions between combinatorial methodologies in Biology and Chemistry. Breakthrough discoveries with replicating biopolymer libraries and chemical combinatorial libraries made the conference timely and allowed synergistic interactions to occur between the participants. For example, this conference was where David Bartel first reported on using a 'reflection selection' technique to identify nucleic acid aptamers that were stable to sera. Dr. Bartel's announcement was quickly picked up on by both academic and corporate scientists, and novel extensions of the work were informally discussed. Another goal of the conference was to begin to chart directions for the future, and to try to anticipate where these broad-ranging fields might be headed. Several of the talks, including the keynote address by Jack Szostak, made apparent how the science of combinatorial chemistry both provides insights into researches into the origins of life and molecular evolution, and ultimately supports more practical applications in industry. One participant, Jack Keene, said that despite a glut of industry conferences on the nuts-and-bolts aspects of combinatorial chemistry, that this was the best conference on the subject that he'd attended.

Descriptors :   *SYMPOSIA, *MOLECULAR BIOLOGY, *LIBRARIES, METHODOLOGY, BIOLOGY, INTERACTIONS, MOLECULES, POLYMERS, CHEMISTRY, COMBINATORIAL ANALYSIS, SYNERGISM, NUCLEIC ACIDS, EVOLUTION(BIOLOGY).

Subject Categories : Information Science
      Genetic Engineering and Molecular Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE