Accession Number : ADA324280

Title :   Molecular Analysis of Preleukemic and Leukemic Bone Marrow from Children with Monosomy V Syndrome and Juvenile Chronic Myelogenous Leukemia.

Descriptive Note : Final rept. 22 Sep 93-21 Sep 96,

Corporate Author : CALIFORNIA UNIV SAN FRANCISCO

Personal Author(s) : Shannon, Kevin M.

PDF Url : ADA324280

Report Date : OCT 1996

Pagination or Media Count : 31

Abstract : The purpose of this study is to understand why children with neurofibromatosis, type 1 (NF1) are at increased risk of developing myeloid leukemia and, in a broader sense, to utilize these cancer cells to generate new knowledge about the role of the NF1 gene (NF1) in growth control. Genetic and biochemical data from our laboratory provide formal proof that NFl acts as a tumor suppressor gene in myeloid cells and regulates growth through its effects on the p21(ras) proteins. Boys with who inherit NF1 from their mothers are especially predisposed to leukemia, and children who receive chemotherapy and radiation for other cancers appear to be at increased risk of secondary leukemia. Finally, our data indicate that the leukemias of some children with no clinical evidence of NF1 carry NFl mutations.

Descriptors :   *CANCER, MUTATIONS, GENES, CHILDREN, CHEMOTHERAPY, SUPPRESSORS, LEUKEMIA, MYELOMA.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE