Accession Number : ADA324313

Title :   NHRC Update. Issue Number 1-5.

Descriptive Note : Bulletins for Mar 96-Apr 97.

Corporate Author : NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA

PDF Url : ADA324313

Report Date : APR 1997

Pagination or Media Count : 21

Abstract : CAPT Stephanie Brodine and her colleagues, including Dr. Frank Garland and Stan Ito from NHRC, and researchers from Walter Reed Army Institute of Research Retrovirology Lab, identified the first cases of U.S. natives infected with the HIV-l strains causing the African and Asian epidemics. This study, published in the November 5, 1995 issue of Lancet, used new state-of-the-art laboratory techniques to identify the specific strains or subtypes of HIV. In the U.S. and Europe, nearly all of the HIV viruses are subtype B, whereas the predominant subtypes in Africa are A, C, and D. Subtype E predominates in Thailand. Differentiating HIV subtypes may have important implications in vaccine development, HIV diagnosis, and the epidemioloy of the epidemic. Given the wide dispersal of HIV-1 subtypes internationally and the routine occurrence of international travel, it seems inevitable that strains other than subtype B eventually will spread in the USA. NHRC is in a unique position to address the question of the introduction of these divergent HIV subtypes into the U.S. as our HIV Central Registry allows identification of recently acquired HIV infections and our powerful databases enable tracking of personnel and their ships' movements.

Descriptors :   *STRAINS(BIOLOGY), *INFECTIOUS DISEASES, *VIRUSES, *HUMAN IMMUNODEFICIENCY VIRUSES, *GENETICS, DATA BASES, EUROPE, POSITION(LOCATION), DISPERSING, STATE OF THE ART, TRACKING, LABORATORY PROCEDURES, TRAVEL, PERSONNEL, INTERNATIONAL, AFRICA, EPIDEMIOLOGY, ASIA, VACCINES, THAILAND, RETROVIRUSES, VIROLOGY.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE