Accession Number : ADA324406
Title : Early Detection of Neurofibromatosis Type-1 Brain Tumor Growth and Treatment Response by Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, and Positron Emission Tomography in a Trial of Novem Antitumor Drugs.
Descriptive Note : Annual rept. 22 Sep 93-21 Sep 96,
Corporate Author : CHILDREN'S HOSPITAL OF PHILADELPHIA PA
Personal Author(s) : Phillips, Peter C. ; Molloy, Patricia T. ; Needle, Michael N. ; Vaughan, Sheila N.
PDF Url : ADA324406
Report Date : OCT 1996
Pagination or Media Count : 341
Abstract : Standard evaluations of NF- 1 tumor and treatment response are inadequate and current therapies are ineffective. We conducted studies using MRI, MRS, and PET in 28 NF-1 patients with newly-diagnosed brain tumors and 7 with progressive tumors. Preliminary results show MRS and PET profiles similar to non-NF1 tumors. Predictive factors have not been identified. However, thalamic hypometabolism and hypoperfusion is significant in these patients. Neuroimaging data requires re-analysis in 9 months after all scheduled studies are completed. To address these problems, we conducted multimodality neuroimaging studies in NF-1 patients with newly-diagnosed or progressive optic nerve/hypothalamic or brain stem tumors to predict the growth potential of these tumor and a randomized clinical trial of new antitumor agents in progressively enlarging OPT/HT and plexiform neurofibromas to rapidly identify potentially effective therapies.
Descriptors : *BRAIN, *SPECTROSCOPY, *NEOPLASMS, *TOMOGRAPHY, *MAGNETIC RESONANCE IMAGING, EMISSION, DETECTION, CLINICAL MEDICINE, GROWTH(PHYSIOLOGY), OPTIC NERVE, POSITRONS, HYPOTHALAMUS, THALAMUS.
Subject Categories : Medicine and Medical Research
Atomic and Molecular Physics and Spectroscopy
Nuclear Physics & Elementary Particle Physics
Distribution Statement : APPROVED FOR PUBLIC RELEASE