Accession Number : ADA324406

Title :   Early Detection of Neurofibromatosis Type-1 Brain Tumor Growth and Treatment Response by Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, and Positron Emission Tomography in a Trial of Novem Antitumor Drugs.

Descriptive Note : Annual rept. 22 Sep 93-21 Sep 96,

Corporate Author : CHILDREN'S HOSPITAL OF PHILADELPHIA PA

Personal Author(s) : Phillips, Peter C. ; Molloy, Patricia T. ; Needle, Michael N. ; Vaughan, Sheila N.

PDF Url : ADA324406

Report Date : OCT 1996

Pagination or Media Count : 341

Abstract : Standard evaluations of NF- 1 tumor and treatment response are inadequate and current therapies are ineffective. We conducted studies using MRI, MRS, and PET in 28 NF-1 patients with newly-diagnosed brain tumors and 7 with progressive tumors. Preliminary results show MRS and PET profiles similar to non-NF1 tumors. Predictive factors have not been identified. However, thalamic hypometabolism and hypoperfusion is significant in these patients. Neuroimaging data requires re-analysis in 9 months after all scheduled studies are completed. To address these problems, we conducted multimodality neuroimaging studies in NF-1 patients with newly-diagnosed or progressive optic nerve/hypothalamic or brain stem tumors to predict the growth potential of these tumor and a randomized clinical trial of new antitumor agents in progressively enlarging OPT/HT and plexiform neurofibromas to rapidly identify potentially effective therapies.

Descriptors :   *BRAIN, *SPECTROSCOPY, *NEOPLASMS, *TOMOGRAPHY, *MAGNETIC RESONANCE IMAGING, EMISSION, DETECTION, CLINICAL MEDICINE, GROWTH(PHYSIOLOGY), OPTIC NERVE, POSITRONS, HYPOTHALAMUS, THALAMUS.

Subject Categories : Medicine and Medical Research
      Atomic and Molecular Physics and Spectroscopy
      Nuclear Physics & Elementary Particle Physics

Distribution Statement : APPROVED FOR PUBLIC RELEASE