Accession Number : ADA324416

Title :   The Effect of Intramedullary Polymethylmethacrylate and Autogenous Cancellous Bone on Healing of Frozen Segmental Allografts,

Corporate Author : WISCONSIN UNIV-MADISON SCHOOL OF VETERINARY MEDICINE

Personal Author(s) : Hanson, Peter D. ; Warner, Chad ; Kofroth, Rachael ; Osmond, Christian ; Bogdanske, John J.

PDF Url : ADA324416

Report Date : FEB 1997

Pagination or Media Count : 57

Abstract : This study was designed to compare limb function, bone mineral density, periosteal callus, new bone, porosity, histology, and union of mid-diaphyseal segmental allografts of the femur stabilized with an interlocking nail (ILN) technique in a dog model. An in vivo study was performed to compare the effects of augmenting ILN fixation with the following: ILN alone (n), ILN plus intramedullary cement (nc), ILN plus intramedullary cement and autogenous cancellous bone applied to the periosteal surface of the host-allograft junction (ncp), ILN plus autogenous cancellous bone applied to the endosteal surface of the allograft (ne), ILN plus autogenous cancellous bone applied to the periosteal surface of the host-allograft junction (np), and ILN plus autogenous cancellous bone applied to the periosteal surface of the host-allograft junction and to the endosteal surface of the allograft (npe). Following allograft implantation, the dogs were evaluated by radiography, dual energy X-ray absorptiometry, and force plate gait analysis from 0 to 24 weeks. Six months after allograft implantation, the dogs were euthanatized and the femora processed for analysis. There were no differences between treatments for limb function or bone mineral density. Callus area 4 weeks after surgery was greater along the lateral and cranial surfaces for treatments receiving periosteal cancellous bone (P<0.05). This was also evident along the caudal surface at 24 weeks (P<0.05). New bone within the allograft segment did not differ between treatments and was reduced compared to the host-allograft junctions (P<0.05). Histologic scores were greatest with treatments 'ncp' and npe', listed above (P<0.05).

Descriptors :   *SURGERY, *LEGS, *BONES, *SKIN GRAFTS, *SURGICAL TRANSPLANTATION, STABILIZATION, FUNCTIONS, DENSITY, POROSITY, JUNCTIONS, IN VIVO ANALYSIS, RADIOGRAPHY, SCORING, MINERALS, DOGS, HEALING, HISTOLOGY, EXTREMITIES.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE