Accession Number : ADA324574

Title :   Inhalation Uptake and Metabolism of Iodohalogenated Compounds, CF3I, C6F13I, and C3F7I.

Descriptive Note : Interim rept. Jun 93-Mar 95,

Corporate Author : MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH

Personal Author(s) : Creech, J. R. ; Black, R. K. ; Garrity, B. L. ; Abbas, R. ; Dong, L.

PDF Url : ADA324574

Report Date : APR 1995

Pagination or Media Count : 24

Abstract : The purpose of this study was to measure the tissue to air partition coefficients and to describe the uptake and distribution kinetics of iodohalogenated compounds iodotrifluoromethane (CF3I), perfluorohexyl iodide (C6F13I) and l-iodoheptafluoropropane (C3F7l) via closed chamber recirculating gas uptake methods. Inhalation pharmacokinetics for all chemicals were determined experimentally in Fischer-344 (F-344) male rats. A physiologically based pharmacokinetic (PBPK) model was used to describe mathematically the disposition and metabolism of the chemicals employing chemical-specific parameters and apparent whole-body metabolic constants calculated from these expenments

Descriptors :   *PHARMACOKINETICS, RATS, DISTRIBUTION, AIR, CHEMICALS, METABOLISM, COEFFICIENTS, CONSTANTS, MALES, KINETICS, INHALATION.

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE