Accession Number : ADA324577

Title :   Serotonin and the Scientific Basis of Anti-Emetic Therapy,

Corporate Author : OXFORD UNIV (UNITED KINGDOM) RADCLIFFE INFIRMARY

Personal Author(s) : Reynolds, D. J. ; Andrews, P. L. ; Davis, C. J.

PDF Url : ADA324577

Report Date : DEC 1995

Pagination or Media Count : 283

Abstract : Emesis research: a concise history of the critical concepts and experiments; The physiology of emesis induced by anti-cancer therapy; The discovery of selective 5-hydroxytryptamine-3 (5-HT3) receptor antagonists; The clinical approach to chemotherapy-induced emesis; How do toxic emetic stimuli cause 5-HT release in the gut and brain?; The role of free radicals and nitric oxide in the induction of emesis; The pharmacology of 5-HT release from enterochromaffin cells; The vagal afferent response to 5-HT and cisplatin; The electrophysiology of vagal and recombinant 5-HT3 receptors; 5-HT3 receptors in the dorsal vagal complex; Where do 5-HT3 receptor antagonists act as anti-emetics?; 5-HT3 receptor antagonists and radiation-induced emesis: preclinical data; Clinical evidence for 5-HT3 receptor antagonist efficacy in radiation-induced emesis; Clinical evidence for the involvement of serotonin in acute cytotoxic-induced emesis; What is the involvement of 5-HT3 receptors in postoperative nausea and vomiting?; Preclinical differences in 5-HT3 receptor antagonist characteristics; Are there any true clinical differences hetween 5-HT3 receptor antagonists?; Limitations in the efficacy of 5-HT3 receptor antagonists; Does 5-HT play a role in the delayed phase of cisplatin-induced emesis?; 5-HT4 receptor involvement in emesis; Are 5-HT3 receptor effects on gastrointestinal motility relevant to anti-emesis?; Opioid receptor involvement in emesis and anti-emesis

Descriptors :   *SEROTONIN, *PHARMACOLOGICAL ANTAGONISTS, *ANTIEMETICS, *EMETICS, *EMESIS, BRAIN, TOXICITY, CLINICAL MEDICINE, THERAPY, PHYSIOLOGY, STIMULI, FREE RADICALS, NITROGEN OXIDES, INDUCTION SYSTEMS, SENSE ORGANS, RADIATION EFFECTS, ELECTROPHYSIOLOGY, GASTROINTESTINAL SYSTEM.

Subject Categories : Anatomy and Physiology
      Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE